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Ehrlichiosis in Dogs

Reviewed by Dr. Sarah Tasse, DVM on Thursday, September 24, 2015
Posted February 21, 2014 in Dog Diseases & Conditions A-Z


[Editor's Note: This article covers E. canis which is only one type of ehrlichiosis. E. ewingii and E. chaffeensis are different infections and create different clinical diseases.]

Ehrlichiosis is an emerging disease caused by a rickettsia: a type of bacteria that infects dogs, people, and less commonly cats. Ehrlichiosis was first recognized as a disease in the United States in the late 1980’s, but did not become a reportable disease (in humans) until 1999. In dogs, most cases of ehrlichiosis are caused by E. canis. Transmission is always from tick bites. Although people and dogs often live in close relationship, and may be infected by, the same species of ticks, direct cross infection is not known to occur.

Ehrlichia is most often transmitted by the Brown dog tick (Rhipicephalus sanguineus). Infection is thought to require several hours of tick to the dog attachment and clinical signs may not demonstrate for 1-3 weeks.

Stages of ehrlichiosis in dogs
There are 3 differing stages of the disease in dogs.
Acute phase of ehrlichiosis:  1-3 weeks after exposure

  • Fever, anorexia, lethargy
  • Enlarged lymph node
  • Thrombocytopenia or low platelet counts

Most dogs recover at this point, but others progress to the subacute and chronic phases.

Subacute phase ehrlichiosis:

  • Hypergammaglobulinemia or abnormally elevated immune proteins
  • Thrombocytopenia and anemia
  • This phase can last months to years

Chronic phase of ehrlichiosis:

  • Lethargy, weight loss
  • Reduction in red and white blood cell counts
  • Bone Marrow Supression and hemorrhage
  • Death

Less commonly, infected dogs can also exhibit inflammatory diseases of the eye and nervous system.

According to The University of Wisconsin, progression to subacute and chronic disease is generally attributed to an ineffective immune response on the part of the dog. German Shepherd dogs appear to be predisposed to the severe, chronic form of disease.

Diagnosing ehrlichia in dogs

  • Most commonly, a presumptive diagnosis is made when clinical signs lead to a high level of suspicion.
  • Monocytes, a kind of white blood cell, can occasionally help with diagnostics.
  • Confirmation may require using an ELISA test that also looks for anaplasma, Lyme disease, and heartworm infection. PCR testing is also becoming commonly available.

Treatment of ehrlichiosis in dogs may include:

Dog On Leash

  • Tetracycline
  • Doxycycline  

Treatment should be maintained for at least 4 weeks.

Prevention of ehrlichiosis

There is no available vaccine and the best ways to prevent these infectious bites are with tick repellents, thorough body

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Mike has more than 35 years of experience in companion animal veterinary practice and is a valued member of IDEXX’s Pet Health Network team since 2013.