to Pet Health Network or

Answers from vets about your dog:

Are Long Term Pain Medications (NSAIDS) Safe for Dogs?

Reviewed by Dr. Celeste Clements, DVM, DACVIM on Tuesday, October 13, 2015
Posted October 15, 2015 in Dog Toxins & Poisons

Just like people, many dogs develop age-related arthritis. Symptoms are far more common in larger breeds. Not only are the big dogs more predisposed to arthritis, their joint pain is intensified because of the extra weight they carry.

Vet giving a dog a pillNonsteroidal anti-inflammatory drugs (NSAIDs)
As their name implies, NSAIDs are non-cortisone containing drugs. They have both anti-inflammatory and analgesic (pain fighting) properties that produce greater ease of movement resulting in muscle strengthening and decreased strain on affected joints. Back in the 80s, when I was just a pup, the only NSAID available for dogs with arthritis pain was aspirin. While this drug did do a pretty good job alleviating arthritis, it also caused plenty of gastrointestinal side effects.

Fast-forward to 2015 and several big-name pharmaceutical companies have their own NSAID brand approved for the treatment of canine arthritis. Within the United States there’s Rimadyl®, Deramaxx®, Previcox™, Metacam®, EtoGesic® Zubrin®, Quellin™ and Novox®all of which are quite effective and associated with far fewer side effects than aspirin.

Just as in people, the specific NSAID brand that most effectively treats arthritis pain in dogs varies from individual to individual. Most veterinarians have their first choice recommendation, but certainly try other NSAIDs should the first choice fail to create significant improvement.

[Check out 'NSAID Medications and Dogs 101' for more]

Potential side effects
As is true for most any drug, negative side effects can occur with NSAID use in dogs. While the actual incidence of side effects is not known, it is thought to be low. When dosed appropriately, the vast majority of dogs tolerate NSAID therapy very well.

There tends to be an unsubstantiated fear that the longer NSAIDs are used, the greater the risk of associated problems. Dr. B. Duncan Lascelles, a professor of surgery and pain management at North Carolina State University College of Veterinary Medicine dispels this notion in a paper titled, “Risk-Benefit Decision Making in the Long-Term Use of NSAIDs for Canine Osteoarthritis.” According to Don Jergler of Veterinary Practice news, Lascelles states,

“We found that this was not true, there was no association between the longer you give a non-steroidal and the risk of side effects. As far as we can tell, we don’t find any relationship between those two things- length of non-steroidal use and incidence of side effects. Often, the clinical approach to a young or middle-aged dog with osteoarthritis associated pain is to avoid the use of NSAIDs. The rationale often quoted for this approach is that the practitioner wants to leave the use of NSAIDs for later, and not have a dog on NSAIDs for the whole of its life. This is a flawed and rather naïve approach.”

Lascelles goes on to say that, when NSAID side effects do occur, they are most likely to appear within the first two to four weeks after beginning therapy.

Gastrointestinal upset, gastrointestinal ulcers, liver toxicity, and kidney toxicity are all possible NSAID associated problems. Signs may include:

Proper screening of the dog by a veterinarian prior to starting NSAID therapy as well as appropriate follow up after medication has started, lessens the potential for adverse reactions. For example, an older arthritic dog discovered to have kidney failure would be ruled out as a good candidate for NSAID therapy. Observation of any side effects warrants immediate discontinuation of the NSAID and discussion with the prescribing veterinarian.

NSAIDs: One of several treatment options
While NSAIDs work well in many dogs, they are not the end-all and be-all treatment for arthritis. As a stand-alone therapy, they are inadequate for some dogs with chronic arthritis pain. Such animals are more likely to benefit from multimodal therapy in which an NSAID is combined with one or more of the following:

  • Weight management
  • Exercise modification
  • Physical rehabilitation (passive stretching, range of motion exercises, swimming, under water treadmill therapy)
  • Supplements/Nutraceuticals (omega-3 fatty acids, glucosamine, hyaluronic acid, chondroitin sulfate, polysulfated glycosaminoglycans)
  • Acupuncture
  • Massage therapy
  • Stem cell therapy
  • Surgery, such as a total hip replacement
  • Pain medications (tramadol, gabapentin, narcotics)
  • Steroids

Share This Article

Nancy has more than 30 years of experience in the veterinary industry and is a board-certified veterinary specialist in internal medicine as well as a valued member of IDEXX’s Pet Health Network team since 2014.