Canine Histoplasmosis

Who knew that the dirt we walk on harbors a fungus called Histoplasma capsulatum that can cause a chronic, noncontagious infection called histoplasmosis in animals and humans. Histoplasmosis is found globally and most commonly affects dogs and cats.

While this fungus can be found anywhere, it likes warm, moist environments best, and thrives especially well in soil that contains bird or bat waste. Histoplasma capsulatum is commonly found in the Mississippi River and Ohio River valleys in the U.S.

How dogs become infected with histoplamosis:

Your dog would most likely become infected with histoplasmosis by inhaling fungal spores, which then set up camp in your dog’s lungs and multiply, causing a localized infection. Your dog can also become infected through oral transmission, where the organism then causes an infection in the intestines. The fungal infection may stay within the lungs or the intestines, or it may spread to other parts of the body, causing a generalized or systemic infection, affecting the lymph nodes, spleen, liver, bone marrow, skin, or eyes.

Dogs that have prolonged exposure to soil with high levels of the fungus are thought to be at greater risk of contracting the disease. Since the organism is found outside, in soil, most dogs that become infected are young and of larger breeds, including those commonly used for hunting.

The symptoms of histoplasmosis are unpredictable and often nonspecific. They can include:

  • Mild fever
  • Depression
  • Weight loss
  • Loss of appetite
  • Labored breathing
  • Persistent diarrhea 
  • Tarry or bloody stools
  • Straining when defecating 
  • Draining skin lesions
  • Eye infection 
  • If the disease has spread and become generalized, your veterinarian may find that your dog’s liver, spleen, and/or lymph nodes are larger than normal, and that your dog’s joints have become affected.

Your veterinarian will perform a thorough physical exam of your pet and take a complete history of her activity and places she visits.

Because the symptoms of histoplasmosis are often vague, your veterinarian may recommend the following screening tests to help support a tentative diagnosis of histoplasmosis:

  • Chemistry tests to evaluate kidney, liver, and pancreatic function, as well as sugar levels
  • Antibody tests to identify if your pet has been exposed to tick-borne or other infectious diseases
  • A complete blood count (CBC) to rule out blood-related conditions
  • Electrolyte tests to ensure your dog isn’t dehydrated or suffering from an electrolyte imbalance
  • Urine tests to screen for urinary tract infection and other disease, and to evaluate the ability of the kidneys to concentrate urine
  • Specialty ELISA or PCR testing of the blood and urine
  • Cytology and/or histopathology; these tests can help to definitively diagnose histoplasmosis by identifying Histoplasma capsulatum microspcopically, with special stains.

Additional tests may be added on an individual basis. Your veterinarian will recommend a course of action that is specific to your pet.



The success of your dog’s treatment depends on her history, physical state, and the diagnostic test results. Additionally, if the disease has spread from the lungs or intestines to other areas of her body, it could have a negative impact on your dog’s prognosis.

Thanks to new advances in antifungal drugs, treatments with fewer serious side effects than those used in the past are now available. Medication may need to be administered for as long as 6 months in order to successfully treat this disease. Your veterinarian will work with you to closely monitor your dog’s tolerance to the medication and response to treatment, and may also recommend routine blood tests and other diagnostic tests at specific intervals throughout treatment.

Limiting your dog’s exposure to high-risk areas is the best way to prevent her from becoming infected with histoplasmosis.

If you have any questions or concerns, you should always visit or call your veterinarian – they are your best resource to ensure the health and well-being of your pets.