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A New Star In The War On Brain Cancer

Posted July 24, 2013 in A Vet's Life

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A rescued Great Dane with cancer may hold the key to a new treatment for humans. Star, the beloved best friend of famed Colorado University Cancer Center neurosurgeon Dr. Michael Graner, was 12 when she was diagnosed with a particularly aggressive form of lung cancer known as advanced bronchoalveolar adenocarcinoma. Most dogs live only 6 to 27 days after diagnosis. At age 12, Star was too old and debilitated to undergo chemotherapy or radiation. Even with the latest chemotherapy protocol, Star would only have a 10 to 15 percent chance of successful treatment. That’s when Dr. Graner decided to try something different.

Working with veterinary researcher Dr. Laura Epple, Graner and his team took cells from Star’s tumors, created a special vaccine to teach the body to fight the cancer, and administered it to Star.Great Dane's eyes Graner and Epple knew the vaccine wouldn’t hurt Star and maybe, just maybe, could help an otherwise helpless pet.

Both doctors realistically expected Star to develop full-blown metastases and decline within days. After all, this was a serious and advanced form of lung cancer. The first week after treatment passed with no worsening of her condition. In fact, Star began to show subtle signs of improvement. Another week, then another passed without incident. Graner noted Star’s quality of life was his highest priority. While Star was no youngster, her quality of life remained good after the experimental cancer vaccine treatment. One month lapsed and still no indication that Star’s cancer was worsening. The vaccine treatment seemed to be working. Finally, 44 weeks later Star began showing signs of the lung cancer’s return and spread. Almost one year from her cancer diagnosis, Star ‘s family made the difficult decision to euthanize her. Star ultimately enjoyed a good quality of life for more than ten times current chemotherapy expectations. Color me impressed.

Star’s case has been published in a medical research journal with the hope her story will inspire additional investigation. Graner is using his experience treating Star’s lung cancer in the fight against one of his biggest enemies as a neurosurgeon, the brain cancer glioblastoma. He hopes to find a way to create a vaccine treatment for humans faced with this devastating brain disease. The goal is to coax the body’s natural immune system into destroying cancer cells, leaving healthy cells

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Ernie has more than 20 years of experience in the veterinary industry and is a well-known veterinarian, media personality and author. He is also a founding member of IDEXX’s Pet Health Network team.

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The opinions and views expressed in this post are those of the author's and do not necessarily represent the beliefs, policies or positions of all veterinarians, Pet Health Network, IDEXX Laboratories, Inc. or its affiliates and partner companies.